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Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review
BACKGROUND: CASR gene appears to be involved in cancer biology and physiology. However, a number of studies investigating CASR polymorphisms and cancer risks have presented inconclusive results. Thus, a systematic review and a meta-analysis of the effect of CASR polymorphisms on several cancer risks...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755434/ https://www.ncbi.nlm.nih.gov/pubmed/26929638 http://dx.doi.org/10.2147/OTT.S97602 |
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author | Jeong, Sohyun Kim, Jae Hyun Kim, Myeong Gyu Han, Nayoung Kim, In-Wha Kim, Therasa Oh, Jung Mi |
author_facet | Jeong, Sohyun Kim, Jae Hyun Kim, Myeong Gyu Han, Nayoung Kim, In-Wha Kim, Therasa Oh, Jung Mi |
author_sort | Jeong, Sohyun |
collection | PubMed |
description | BACKGROUND: CASR gene appears to be involved in cancer biology and physiology. However, a number of studies investigating CASR polymorphisms and cancer risks have presented inconclusive results. Thus, a systematic review and a meta-analysis of the effect of CASR polymorphisms on several cancer risks were performed to suggest a statistical evidence for the association of CASR polymorphisms with cancer risks. METHODS: MEDLINE, EMBASE, Web of Science, Scopus, and the HuGE databases were searched. Nineteen articles of case–control and cohort studies were included for the final analysis. RESULTS: The colorectal cancer risk was reduced in proximal (odds ratio [OR] =0.679, P=0.001) and distal (OR =0.753, P=0.026) colon sites with GG genotype of CASR rs1042636 and increased in distal colon site (OR =1.418, P=0.039) with GG genotype of rs1801726 by additive genetic model. The rs17251221 demonstrated noticeable associations that carrying a homozygote variant increases breast and prostate cancer risk considerably. CONCLUSION: The significant association of CASR polymorphisms with several cancer risks was observed in this review. In particular, the act of CASR polymorphisms as a tumor suppressor or an oncogene differs by cancer site and can be the research target for tumorigenesis. |
format | Online Article Text |
id | pubmed-4755434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47554342016-02-29 Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review Jeong, Sohyun Kim, Jae Hyun Kim, Myeong Gyu Han, Nayoung Kim, In-Wha Kim, Therasa Oh, Jung Mi Onco Targets Ther Review BACKGROUND: CASR gene appears to be involved in cancer biology and physiology. However, a number of studies investigating CASR polymorphisms and cancer risks have presented inconclusive results. Thus, a systematic review and a meta-analysis of the effect of CASR polymorphisms on several cancer risks were performed to suggest a statistical evidence for the association of CASR polymorphisms with cancer risks. METHODS: MEDLINE, EMBASE, Web of Science, Scopus, and the HuGE databases were searched. Nineteen articles of case–control and cohort studies were included for the final analysis. RESULTS: The colorectal cancer risk was reduced in proximal (odds ratio [OR] =0.679, P=0.001) and distal (OR =0.753, P=0.026) colon sites with GG genotype of CASR rs1042636 and increased in distal colon site (OR =1.418, P=0.039) with GG genotype of rs1801726 by additive genetic model. The rs17251221 demonstrated noticeable associations that carrying a homozygote variant increases breast and prostate cancer risk considerably. CONCLUSION: The significant association of CASR polymorphisms with several cancer risks was observed in this review. In particular, the act of CASR polymorphisms as a tumor suppressor or an oncogene differs by cancer site and can be the research target for tumorigenesis. Dove Medical Press 2016-02-09 /pmc/articles/PMC4755434/ /pubmed/26929638 http://dx.doi.org/10.2147/OTT.S97602 Text en © 2016 Jeong et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Jeong, Sohyun Kim, Jae Hyun Kim, Myeong Gyu Han, Nayoung Kim, In-Wha Kim, Therasa Oh, Jung Mi Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review |
title | Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review |
title_full | Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review |
title_fullStr | Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review |
title_full_unstemmed | Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review |
title_short | Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review |
title_sort | genetic polymorphisms of casr and cancer risk: evidence from meta-analysis and huge review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755434/ https://www.ncbi.nlm.nih.gov/pubmed/26929638 http://dx.doi.org/10.2147/OTT.S97602 |
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