The pharmacogenomics of pain management: prospects for personalized medicine

Pain is a common symptom that can be complex to treat. Analgesic medications are the mainstay treatment, but there is wide interindividual variability in analgesic response and adverse effects. Pharmacogenomics is the study of inherited genetic traits that result in these individual responses to dru...

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Detalles Bibliográficos
Autores principales: Ting, Sonya, Schug, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755469/
https://www.ncbi.nlm.nih.gov/pubmed/26929662
http://dx.doi.org/10.2147/JPR.S55595
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author Ting, Sonya
Schug, Stephan
author_facet Ting, Sonya
Schug, Stephan
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description Pain is a common symptom that can be complex to treat. Analgesic medications are the mainstay treatment, but there is wide interindividual variability in analgesic response and adverse effects. Pharmacogenomics is the study of inherited genetic traits that result in these individual responses to drugs. This narrative review will attempt to cover the current understanding of the pharmacogenomics of pain, examining common genes affecting metabolism of analgesic medications, their distribution throughout the body, and end organ effects.
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spelling pubmed-47554692016-02-29 The pharmacogenomics of pain management: prospects for personalized medicine Ting, Sonya Schug, Stephan J Pain Res Review Pain is a common symptom that can be complex to treat. Analgesic medications are the mainstay treatment, but there is wide interindividual variability in analgesic response and adverse effects. Pharmacogenomics is the study of inherited genetic traits that result in these individual responses to drugs. This narrative review will attempt to cover the current understanding of the pharmacogenomics of pain, examining common genes affecting metabolism of analgesic medications, their distribution throughout the body, and end organ effects. Dove Medical Press 2016-02-10 /pmc/articles/PMC4755469/ /pubmed/26929662 http://dx.doi.org/10.2147/JPR.S55595 Text en © 2016 Ting and Schug. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Ting, Sonya
Schug, Stephan
The pharmacogenomics of pain management: prospects for personalized medicine
title The pharmacogenomics of pain management: prospects for personalized medicine
title_full The pharmacogenomics of pain management: prospects for personalized medicine
title_fullStr The pharmacogenomics of pain management: prospects for personalized medicine
title_full_unstemmed The pharmacogenomics of pain management: prospects for personalized medicine
title_short The pharmacogenomics of pain management: prospects for personalized medicine
title_sort pharmacogenomics of pain management: prospects for personalized medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755469/
https://www.ncbi.nlm.nih.gov/pubmed/26929662
http://dx.doi.org/10.2147/JPR.S55595
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