Cargando…
Deciphering the mode of action of the processive polysaccharide modifying enzyme dermatan sulfate epimerase 1 by hydrogen–deuterium exchange mass spectrometry
Distinct from template-directed biosynthesis of nucleic acids and proteins, the enzymatic synthesis of heterogeneous polysaccharides is a complex process that is difficult to study using common analytical tools. Therefore, the mode of action and processivity of those enzymes are largely unknown. Der...
Autores principales: | Tykesson, Emil, Mao, Yang, Maccarana, Marco, Pu, Yi, Gao, Jinshan, Lin, Cheng, Zaia, Joseph, Westergren-Thorsson, Gunilla, Ellervik, Ulf, Malmström, Lars, Malmström, Anders |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755500/ https://www.ncbi.nlm.nih.gov/pubmed/26900446 http://dx.doi.org/10.1039/c5sc03798k |
Ejemplares similares
-
Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin
por: Tykesson, Emil, et al.
Publicado: (2019) -
The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
por: Hasan, Mahmudul, et al.
Publicado: (2020) -
Biological functions of iduronic acid in chondroitin/dermatan sulfate
por: Thelin, Martin A, et al.
Publicado: (2013) -
Dermatan sulfate epimerase 1 deficient mice as a model for human abdominal wall defects
por: Gustafsson, Renata, et al.
Publicado: (2014) -
Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis
por: Stachtea, Xanthi N., et al.
Publicado: (2015)