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Mps1(Mph1) Kinase Phosphorylates Mad3 to Inhibit Cdc20(Slp1)-APC/C and Maintain Spindle Checkpoint Arrests

The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkp...

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Detalles Bibliográficos
Autores principales:	Zich, Judith, May, Karen, Paraskevopoulos, Konstantinos, Sen, Onur, Syred, Heather M., van der Sar, Sjaak, Patel, Hitesh, Moresco, James J., Sarkeshik, Ali, Yates, John R., Rappsilber, Juri, Hardwick, Kevin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755545/ https://www.ncbi.nlm.nih.gov/pubmed/26882497 http://dx.doi.org/10.1371/journal.pgen.1005834

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