Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

BACKGROUND: Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in healthy patients (for up to 21 days) and st...

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Detalles Bibliográficos
Autores principales: Pohlig, Gabriele, Bernhard, Sonja C., Blum, Johannes, Burri, Christian, Mpanya, Alain, Lubaki, Jean-Pierre Fina, Mpoto, Alfred Mpoo, Munungu, Blaise Fungula, N’tombe, Patrick Mangoni, Deo, Gratias Kambau Manesa, Mutantu, Pierre Nsele, Kuikumbi, Florent Mbo, Mintwo, Alain Fukinsia, Munungi, Augustin Kayeye, Dala, Amadeu, Macharia, Stephen, Bilenge, Constantin Miaka Mia, Mesu, Victor Kande Betu Ku, Franco, Jose Ramon, Dituvanga, Ndinga Dieyi, Tidwell, Richard R., Olson, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755561/
https://www.ncbi.nlm.nih.gov/pubmed/26882015
http://dx.doi.org/10.1371/journal.pntd.0004363

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