The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly exerts its function as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage lead...

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Detalles Bibliográficos
Autores principales: Brunati, Martina, Perucca, Simone, Han, Ling, Cattaneo, Angela, Consolato, Francesco, Andolfo, Annapaola, Schaeffer, Céline, Olinger, Eric, Peng, Jianhao, Santambrogio, Sara, Perrier, Romain, Li, Shuo, Bokhove, Marcel, Bachi, Angela, Hummler, Edith, Devuyst, Olivier, Wu, Qingyu, Jovine, Luca, Rampoldi, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755741/
https://www.ncbi.nlm.nih.gov/pubmed/26673890
http://dx.doi.org/10.7554/eLife.08887

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