The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen. The LPL•GPIHBP1 complex is responsible for margination of triglyceride-rich lipoproteins along capillaries and th...

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Detalles Bibliográficos
Autores principales: Mysling, Simon, Kristensen, Kristian Kølby, Larsson, Mikael, Beigneux, Anne P, Gårdsvoll, Henrik, Fong, Loren G, Bensadouen, André, Jørgensen, Thomas JD, Young, Stephen G, Ploug, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755760/
https://www.ncbi.nlm.nih.gov/pubmed/26725083
http://dx.doi.org/10.7554/eLife.12095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755760/
https://www.ncbi.nlm.nih.gov/pubmed/26725083
http://dx.doi.org/10.7554/eLife.12095

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