CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors

The role that anergy, an acquired state of T cell functional unresponsiveness, plays in natural peripheral tolerance remains unclear. In this study, we demonstrate that anergy is selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulati...

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Detalles Bibliográficos
Autores principales: Kalekar, Lokesh A., Schmiel, Shirdi E., Nandiwada, Sarada L., Lam, Wing Y., Barsness, Laura O., Zhang, Na, Stritesky, Gretta L., Malhotra, Deepali, Pauken, Kristen E., Linehan, Jonathan L., O’Sullivan, M. Gerard, Fife, Brian T., Hogquist, Kristin A., Jenkins, Marc K., Mueller, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755884/
https://www.ncbi.nlm.nih.gov/pubmed/26829766
http://dx.doi.org/10.1038/ni.3331

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