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Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers

The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). We updated the mortality of 714...

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Autores principales: Proctor, Deborah M, Suh, Mina, Mittal, Liz, Hirsch, Shawn, Valdes Salgado, Raydel, Bartlett, Chris, Van Landingham, Cynthia, Rohr, Annette, Crump, Kenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756268/
https://www.ncbi.nlm.nih.gov/pubmed/26669850
http://dx.doi.org/10.1038/jes.2015.77
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author Proctor, Deborah M
Suh, Mina
Mittal, Liz
Hirsch, Shawn
Valdes Salgado, Raydel
Bartlett, Chris
Van Landingham, Cynthia
Rohr, Annette
Crump, Kenny
author_facet Proctor, Deborah M
Suh, Mina
Mittal, Liz
Hirsch, Shawn
Valdes Salgado, Raydel
Bartlett, Chris
Van Landingham, Cynthia
Rohr, Annette
Crump, Kenny
author_sort Proctor, Deborah M
collection PubMed
description The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). We updated the mortality of 714 Painesville workers (including 198 short-term workers) through December 2011, reconstructed exposures, and conducted exposure-response modeling using Poisson and Cox regressions to provide quantitative lung cancer risk estimates. The average length of follow-up was 34.4 years with 24,535 person-years at risk. Lung cancer was significantly increased for the cohort (standardized mortality ratio (SMR)=186; 95% confidence interval (CI) 145–228), for those hired before 1959, those with >30-year tenure, and those with cumulative exposure >1.41 mg/m(3)-years or highest monthly exposures >0.26 mg/m(3). Of the models assessed, the linear Cox model with unlagged cumulative exposure provided the best fit and was preferred. Smoking and age at hire were also significant predictors of lung cancer mortality. Adjusting for these variables, the occupational unit risk was 0.00166 (95% CI 0.000713–0.00349), and the environmental unit risk was 0.00832 (95% CI 0.00359–0.0174), which are 20% and 15% lower, respectively, than values developed in a previous study of this cohort.
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spelling pubmed-47562682016-03-03 Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers Proctor, Deborah M Suh, Mina Mittal, Liz Hirsch, Shawn Valdes Salgado, Raydel Bartlett, Chris Van Landingham, Cynthia Rohr, Annette Crump, Kenny J Expo Sci Environ Epidemiol Original Article The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). We updated the mortality of 714 Painesville workers (including 198 short-term workers) through December 2011, reconstructed exposures, and conducted exposure-response modeling using Poisson and Cox regressions to provide quantitative lung cancer risk estimates. The average length of follow-up was 34.4 years with 24,535 person-years at risk. Lung cancer was significantly increased for the cohort (standardized mortality ratio (SMR)=186; 95% confidence interval (CI) 145–228), for those hired before 1959, those with >30-year tenure, and those with cumulative exposure >1.41 mg/m(3)-years or highest monthly exposures >0.26 mg/m(3). Of the models assessed, the linear Cox model with unlagged cumulative exposure provided the best fit and was preferred. Smoking and age at hire were also significant predictors of lung cancer mortality. Adjusting for these variables, the occupational unit risk was 0.00166 (95% CI 0.000713–0.00349), and the environmental unit risk was 0.00832 (95% CI 0.00359–0.0174), which are 20% and 15% lower, respectively, than values developed in a previous study of this cohort. Nature Publishing Group 2016-03 2015-12-16 /pmc/articles/PMC4756268/ /pubmed/26669850 http://dx.doi.org/10.1038/jes.2015.77 Text en Copyright © 2016 Nature America, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
Proctor, Deborah M
Suh, Mina
Mittal, Liz
Hirsch, Shawn
Valdes Salgado, Raydel
Bartlett, Chris
Van Landingham, Cynthia
Rohr, Annette
Crump, Kenny
Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers
title Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers
title_full Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers
title_fullStr Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers
title_full_unstemmed Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers
title_short Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers
title_sort inhalation cancer risk assessment of hexavalent chromium based on updated mortality for painesville chromate production workers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756268/
https://www.ncbi.nlm.nih.gov/pubmed/26669850
http://dx.doi.org/10.1038/jes.2015.77
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