Small RAB GTPases Regulate Multiple Steps of Mitosis

GTPases of the RAB family are key regulators of multiple steps of membrane trafficking. Several members of the RAB GTPase family have been implicated in mitotic progression. In this review, we will first focus on the function of endosome-associated RAB GTPases reported in early steps of mitosis, spi...

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Detalles Bibliográficos
Autores principales: Miserey-Lenkei, Stéphanie, Colombo, María I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756281/
https://www.ncbi.nlm.nih.gov/pubmed/26925400
http://dx.doi.org/10.3389/fcell.2016.00002
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author Miserey-Lenkei, Stéphanie
Colombo, María I.
author_facet Miserey-Lenkei, Stéphanie
Colombo, María I.
author_sort Miserey-Lenkei, Stéphanie
collection PubMed
description GTPases of the RAB family are key regulators of multiple steps of membrane trafficking. Several members of the RAB GTPase family have been implicated in mitotic progression. In this review, we will first focus on the function of endosome-associated RAB GTPases reported in early steps of mitosis, spindle pole maturation, and during cytokinesis. Second, we will discuss the role of Golgi-associated RAB GTPases at the metaphase/anaphase transition and during cytokinesis.
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spelling pubmed-47562812016-02-26 Small RAB GTPases Regulate Multiple Steps of Mitosis Miserey-Lenkei, Stéphanie Colombo, María I. Front Cell Dev Biol Cell and Developmental Biology GTPases of the RAB family are key regulators of multiple steps of membrane trafficking. Several members of the RAB GTPase family have been implicated in mitotic progression. In this review, we will first focus on the function of endosome-associated RAB GTPases reported in early steps of mitosis, spindle pole maturation, and during cytokinesis. Second, we will discuss the role of Golgi-associated RAB GTPases at the metaphase/anaphase transition and during cytokinesis. Frontiers Media S.A. 2016-02-17 /pmc/articles/PMC4756281/ /pubmed/26925400 http://dx.doi.org/10.3389/fcell.2016.00002 Text en Copyright © 2016 Miserey-Lenkei and Colombo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Miserey-Lenkei, Stéphanie
Colombo, María I.
Small RAB GTPases Regulate Multiple Steps of Mitosis
title Small RAB GTPases Regulate Multiple Steps of Mitosis
title_full Small RAB GTPases Regulate Multiple Steps of Mitosis
title_fullStr Small RAB GTPases Regulate Multiple Steps of Mitosis
title_full_unstemmed Small RAB GTPases Regulate Multiple Steps of Mitosis
title_short Small RAB GTPases Regulate Multiple Steps of Mitosis
title_sort small rab gtpases regulate multiple steps of mitosis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756281/
https://www.ncbi.nlm.nih.gov/pubmed/26925400
http://dx.doi.org/10.3389/fcell.2016.00002
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