A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active DNA damage response (DDR), but its molecular determinants have remained elusive. Here we show in cultured ESCs and mouse embryos that H2AX p...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahuja, Akshay K., Jodkowska, Karolina, Teloni, Federico, Bizard, Anna H., Zellweger, Ralph, Herrador, Raquel, Ortega, Sagrario, Hickson, Ian D., Altmeyer, Matthias, Mendez, Juan, Lopes, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756311/
https://www.ncbi.nlm.nih.gov/pubmed/26876348
http://dx.doi.org/10.1038/ncomms10660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756311/
https://www.ncbi.nlm.nih.gov/pubmed/26876348
http://dx.doi.org/10.1038/ncomms10660

Ejemplares similares