Pitfalls of haplotype phasing from amplicon-based long-read sequencing

The long-read sequencers from Pacific Bioscience (PacBio) and Oxford Nanopore Technologies (ONT) offer the opportunity to phase mutations multiple kilobases apart directly from sequencing reads. In this study, we used long-range PCR with ONT and PacBio sequencing to phase two variants 9 kb apart in...

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Detalles Bibliográficos
Autores principales: Laver, Thomas W., Caswell, Richard C., Moore, Karen A., Poschmann, Jeremie, Johnson, Matthew B., Owens, Martina M., Ellard, Sian, Paszkiewicz, Konrad H., Weedon, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756330/
https://www.ncbi.nlm.nih.gov/pubmed/26883533
http://dx.doi.org/10.1038/srep21746

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