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Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects

Various lines of published evidence have already demonstrated the impact of TRPV1 agonists on energetic metabolism through the stimulation of the sympathetic nervous system (SNS). This study presents a trial investigating if stimulation of the two related sensory receptors TRPA1 and TRPM8 could also...

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Autores principales: Michlig, Stéphanie, Merlini, Jenny Meylan, Beaumont, Maurice, Ledda, Mirko, Tavenard, Aude, Mukherjee, Rajat, Camacho, Susana, le Coutre, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756362/
https://www.ncbi.nlm.nih.gov/pubmed/26883089
http://dx.doi.org/10.1038/srep20795
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author Michlig, Stéphanie
Merlini, Jenny Meylan
Beaumont, Maurice
Ledda, Mirko
Tavenard, Aude
Mukherjee, Rajat
Camacho, Susana
le Coutre, Johannes
author_facet Michlig, Stéphanie
Merlini, Jenny Meylan
Beaumont, Maurice
Ledda, Mirko
Tavenard, Aude
Mukherjee, Rajat
Camacho, Susana
le Coutre, Johannes
author_sort Michlig, Stéphanie
collection PubMed
description Various lines of published evidence have already demonstrated the impact of TRPV1 agonists on energetic metabolism through the stimulation of the sympathetic nervous system (SNS). This study presents a trial investigating if stimulation of the two related sensory receptors TRPA1 and TRPM8 could also stimulate the SNS and impact the energetic metabolism of healthy subjects. The trial was designed to be double-blinded, randomized, cross-over, placebo-controlled with healthy subjects and the impact on the energetic metabolism and the autonomic nervous system (ANS) of cinnamaldehyde, capsaicin and a cooling flavor was measured during the 90 min after ingestion. Energy expenditure and substrate oxidation were measured by indirect calorimetry. An exploratory method to measure ANS activity was by facial thermography and power spectral analysis of heart rate variability using ECG was also used. Following cinnamaldehyde ingestion, energy expenditure was increased as compared to placebo. Furthermore, postprandial fat oxidation was maintained higher compared to placebo after cinnamaldehyde and capsaicin ingestion. Similar peripheral thermoregulation was observed after capsaicin and cinnamaldehyde ingestion. Unlike capsaicin, the dose of cinnamaldehyde was not judged to be sensorially ‘too intense’ by participants suggesting that Cinnamaldehyde would be a more tolerable solution to improve thermogenesis via spicy ingredients as compared to capsaicin.
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spelling pubmed-47563622016-02-25 Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects Michlig, Stéphanie Merlini, Jenny Meylan Beaumont, Maurice Ledda, Mirko Tavenard, Aude Mukherjee, Rajat Camacho, Susana le Coutre, Johannes Sci Rep Article Various lines of published evidence have already demonstrated the impact of TRPV1 agonists on energetic metabolism through the stimulation of the sympathetic nervous system (SNS). This study presents a trial investigating if stimulation of the two related sensory receptors TRPA1 and TRPM8 could also stimulate the SNS and impact the energetic metabolism of healthy subjects. The trial was designed to be double-blinded, randomized, cross-over, placebo-controlled with healthy subjects and the impact on the energetic metabolism and the autonomic nervous system (ANS) of cinnamaldehyde, capsaicin and a cooling flavor was measured during the 90 min after ingestion. Energy expenditure and substrate oxidation were measured by indirect calorimetry. An exploratory method to measure ANS activity was by facial thermography and power spectral analysis of heart rate variability using ECG was also used. Following cinnamaldehyde ingestion, energy expenditure was increased as compared to placebo. Furthermore, postprandial fat oxidation was maintained higher compared to placebo after cinnamaldehyde and capsaicin ingestion. Similar peripheral thermoregulation was observed after capsaicin and cinnamaldehyde ingestion. Unlike capsaicin, the dose of cinnamaldehyde was not judged to be sensorially ‘too intense’ by participants suggesting that Cinnamaldehyde would be a more tolerable solution to improve thermogenesis via spicy ingredients as compared to capsaicin. Nature Publishing Group 2016-02-17 /pmc/articles/PMC4756362/ /pubmed/26883089 http://dx.doi.org/10.1038/srep20795 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Michlig, Stéphanie
Merlini, Jenny Meylan
Beaumont, Maurice
Ledda, Mirko
Tavenard, Aude
Mukherjee, Rajat
Camacho, Susana
le Coutre, Johannes
Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
title Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
title_full Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
title_fullStr Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
title_full_unstemmed Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
title_short Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
title_sort effects of trp channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756362/
https://www.ncbi.nlm.nih.gov/pubmed/26883089
http://dx.doi.org/10.1038/srep20795
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