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Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study

BACKGROUND: Oesophagogastric adenocarcinoma (OGA) has a poor prognosis, even for patients with operable disease. However, the optimal surveillance strategy following surgery is unknown. METHODS: We performed a retrospective review of all patients with OGA who had undergone surgery with radical inten...

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Autores principales: Moorcraft, Sing Yu, Fontana, Elisa, Cunningham, David, Peckitt, Clare, Waddell, Tom, Smyth, Elizabeth C., Allum, William, Thompson, Jeremy, Rao, Sheela, Watkins, David, Starling, Naureen, Chau, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756463/
https://www.ncbi.nlm.nih.gov/pubmed/26883815
http://dx.doi.org/10.1186/s12885-016-2145-0
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author Moorcraft, Sing Yu
Fontana, Elisa
Cunningham, David
Peckitt, Clare
Waddell, Tom
Smyth, Elizabeth C.
Allum, William
Thompson, Jeremy
Rao, Sheela
Watkins, David
Starling, Naureen
Chau, Ian
author_facet Moorcraft, Sing Yu
Fontana, Elisa
Cunningham, David
Peckitt, Clare
Waddell, Tom
Smyth, Elizabeth C.
Allum, William
Thompson, Jeremy
Rao, Sheela
Watkins, David
Starling, Naureen
Chau, Ian
author_sort Moorcraft, Sing Yu
collection PubMed
description BACKGROUND: Oesophagogastric adenocarcinoma (OGA) has a poor prognosis, even for patients with operable disease. However, the optimal surveillance strategy following surgery is unknown. METHODS: We performed a retrospective review of all patients with OGA who had undergone surgery with radical intent at the Royal Marsden between January 2001 and December 2010. RESULTS: Of the 360 patients with OGA who underwent potentially curative surgery, 100/214 patients (47 %) with oesophageal/gastro-oesophageal junction (GOJ) adenocarcinoma and 47/146 patients (32 %) with gastric adenocarcinoma developed recurrent disease. 51, 79 and 92 % of relapses occurred within 1, 2 and 3 years respectively and the majority of patients relapsed at distant sites. Of the patients who relapsed, 67 % (67/100) with oesophageal/GOJ adenocarcinoma and 72 % of patients with gastric cancer (34/47) were symptomatic at the time of relapse. The majority of asymptomatic relapses were first detected by a rise in tumour markers. There was no difference in disease-free survival between asymptomatic and symptomatic patients, but asymptomatic patients were more likely to receive further treatment and had a longer survival beyond relapse. CONCLUSION: The majority of relapses occur within the first 3 years and at distant sites. Monitoring of tumour markers should be considered as part of a surveillance program.
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spelling pubmed-47564632016-02-18 Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study Moorcraft, Sing Yu Fontana, Elisa Cunningham, David Peckitt, Clare Waddell, Tom Smyth, Elizabeth C. Allum, William Thompson, Jeremy Rao, Sheela Watkins, David Starling, Naureen Chau, Ian BMC Cancer Research Article BACKGROUND: Oesophagogastric adenocarcinoma (OGA) has a poor prognosis, even for patients with operable disease. However, the optimal surveillance strategy following surgery is unknown. METHODS: We performed a retrospective review of all patients with OGA who had undergone surgery with radical intent at the Royal Marsden between January 2001 and December 2010. RESULTS: Of the 360 patients with OGA who underwent potentially curative surgery, 100/214 patients (47 %) with oesophageal/gastro-oesophageal junction (GOJ) adenocarcinoma and 47/146 patients (32 %) with gastric adenocarcinoma developed recurrent disease. 51, 79 and 92 % of relapses occurred within 1, 2 and 3 years respectively and the majority of patients relapsed at distant sites. Of the patients who relapsed, 67 % (67/100) with oesophageal/GOJ adenocarcinoma and 72 % of patients with gastric cancer (34/47) were symptomatic at the time of relapse. The majority of asymptomatic relapses were first detected by a rise in tumour markers. There was no difference in disease-free survival between asymptomatic and symptomatic patients, but asymptomatic patients were more likely to receive further treatment and had a longer survival beyond relapse. CONCLUSION: The majority of relapses occur within the first 3 years and at distant sites. Monitoring of tumour markers should be considered as part of a surveillance program. BioMed Central 2016-02-17 /pmc/articles/PMC4756463/ /pubmed/26883815 http://dx.doi.org/10.1186/s12885-016-2145-0 Text en © Moorcraft et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Moorcraft, Sing Yu
Fontana, Elisa
Cunningham, David
Peckitt, Clare
Waddell, Tom
Smyth, Elizabeth C.
Allum, William
Thompson, Jeremy
Rao, Sheela
Watkins, David
Starling, Naureen
Chau, Ian
Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
title Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
title_full Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
title_fullStr Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
title_full_unstemmed Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
title_short Characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
title_sort characterising timing and pattern of relapse following surgery for localised oesophagogastric adenocarcinoma: a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756463/
https://www.ncbi.nlm.nih.gov/pubmed/26883815
http://dx.doi.org/10.1186/s12885-016-2145-0
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