Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

BACKGROUND: Aberrant Wnt signaling activation occurs commonly in colorectal carcinogenesis, leading to upregulation of many target genes. APC (adenomatous polyposis coli) is an important component of the β-catenin destruction complex, which regulates Wnt signaling, and is often mutated in colorectal...

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Detalles Bibliográficos
Autores principales: Savio, Andrea J., Daftary, Darshana, Dicks, Elizabeth, Buchanan, Daniel D., Parfrey, Patrick S., Young, Joanne P., Weisenberger, Daniel, Green, Roger C., Gallinger, Steven, McLaughlin, John R., Knight, Julia A., Bapat, Bharati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756469/
https://www.ncbi.nlm.nih.gov/pubmed/26884349
http://dx.doi.org/10.1186/s12885-016-2149-9

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