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Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients

Primary aldosteronism not only results in hypertension but also stiffer arteries. The time course and factors predicting the reversal of arterial stiffness after treatment are unclear. We prospectively enrolled 102 patients with aldosterone-producing adenoma (APA) from March 2006 to January 2012. We...

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Autores principales: Liao, Che-Wei, Lin, Lian-Yu, Hung, Chi-Sheng, Lin, Yen-Tin, Chang, Yi-Yao, Wang, Shuo-Meng, Wu, Vin-Cent, Wu, Kwan-Dun, Ho, Yi-Lwun, Satoh, Fumitoshi, Lin, Yen-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756682/
https://www.ncbi.nlm.nih.gov/pubmed/26883298
http://dx.doi.org/10.1038/srep20862
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author Liao, Che-Wei
Lin, Lian-Yu
Hung, Chi-Sheng
Lin, Yen-Tin
Chang, Yi-Yao
Wang, Shuo-Meng
Wu, Vin-Cent
Wu, Kwan-Dun
Ho, Yi-Lwun
Satoh, Fumitoshi
Lin, Yen-Hung
author_facet Liao, Che-Wei
Lin, Lian-Yu
Hung, Chi-Sheng
Lin, Yen-Tin
Chang, Yi-Yao
Wang, Shuo-Meng
Wu, Vin-Cent
Wu, Kwan-Dun
Ho, Yi-Lwun
Satoh, Fumitoshi
Lin, Yen-Hung
author_sort Liao, Che-Wei
collection PubMed
description Primary aldosteronism not only results in hypertension but also stiffer arteries. The time course and factors predicting the reversal of arterial stiffness after treatment are unclear. We prospectively enrolled 102 patients with aldosterone-producing adenoma (APA) from March 2006 to January 2012. We measured the pulse wave velocity (PWV) between brachial-ankle (baPWV) and heart-ankle (haPWV) before, 6 and 12 months after their adrenalectomy. After treatment, the PWV decreased significantly during the first 6 months (both p < 0.001), but no further reduction in the following 6 months. The determinant factors for baseline baPWV were age, duration of hypertension, and baseline systolic blood pressure (SBP) in multivariate linear regression analysis, similar with baseline haPWV (determinants: age, duration of hypertension, baseline SBP and diastolic blood pressure (DBP)). In multivariate linear regression analysis, the decrease in DBP at 6 months (ΔDBP(0-6mo)) and baseline baPWV were significantly associated with the decrease in baPWV at 6 months (ΔbaPWV(0-6mo)). The associated factors of the change in haPWV at 6 months (ΔhaPWV(0-6mo)) were baseline haPWV, ΔDBP(0-6mo) and change in log-transformed plasma renin activity. Our result suggested that reversal of arterial stiffness in APA patients occurred early after adrenalectomy and determined by baseline vascular condition, hemodynamic factors, and humoral factors.
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spelling pubmed-47566822016-02-25 Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients Liao, Che-Wei Lin, Lian-Yu Hung, Chi-Sheng Lin, Yen-Tin Chang, Yi-Yao Wang, Shuo-Meng Wu, Vin-Cent Wu, Kwan-Dun Ho, Yi-Lwun Satoh, Fumitoshi Lin, Yen-Hung Sci Rep Article Primary aldosteronism not only results in hypertension but also stiffer arteries. The time course and factors predicting the reversal of arterial stiffness after treatment are unclear. We prospectively enrolled 102 patients with aldosterone-producing adenoma (APA) from March 2006 to January 2012. We measured the pulse wave velocity (PWV) between brachial-ankle (baPWV) and heart-ankle (haPWV) before, 6 and 12 months after their adrenalectomy. After treatment, the PWV decreased significantly during the first 6 months (both p < 0.001), but no further reduction in the following 6 months. The determinant factors for baseline baPWV were age, duration of hypertension, and baseline systolic blood pressure (SBP) in multivariate linear regression analysis, similar with baseline haPWV (determinants: age, duration of hypertension, baseline SBP and diastolic blood pressure (DBP)). In multivariate linear regression analysis, the decrease in DBP at 6 months (ΔDBP(0-6mo)) and baseline baPWV were significantly associated with the decrease in baPWV at 6 months (ΔbaPWV(0-6mo)). The associated factors of the change in haPWV at 6 months (ΔhaPWV(0-6mo)) were baseline haPWV, ΔDBP(0-6mo) and change in log-transformed plasma renin activity. Our result suggested that reversal of arterial stiffness in APA patients occurred early after adrenalectomy and determined by baseline vascular condition, hemodynamic factors, and humoral factors. Nature Publishing Group 2016-02-17 /pmc/articles/PMC4756682/ /pubmed/26883298 http://dx.doi.org/10.1038/srep20862 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liao, Che-Wei
Lin, Lian-Yu
Hung, Chi-Sheng
Lin, Yen-Tin
Chang, Yi-Yao
Wang, Shuo-Meng
Wu, Vin-Cent
Wu, Kwan-Dun
Ho, Yi-Lwun
Satoh, Fumitoshi
Lin, Yen-Hung
Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
title Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
title_full Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
title_fullStr Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
title_full_unstemmed Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
title_short Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
title_sort time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756682/
https://www.ncbi.nlm.nih.gov/pubmed/26883298
http://dx.doi.org/10.1038/srep20862
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