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AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice

Current barriers to the use of adeno-associated virus serotype 9 (AAV9) in clinical trials for treating neurological disorders are its high expression in many off-target tissues such as liver and heart, and lack of cell specificity within the central nervous system (CNS) when using ubiquitous promot...

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Detalles Bibliográficos
Autores principales:	Lukashchuk, Vera, Lewis, Katherine E, Coldicott, Ian, Grierson, Andrew J, Azzouz, Mimoun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756767/ https://www.ncbi.nlm.nih.gov/pubmed/26942208 http://dx.doi.org/10.1038/mtm.2015.55

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