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Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation

Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMps1 also participates in the repair of oxidative DNA lesions and cell survival through the MDM2-H2B axis. In response to oxidative stress, hMps1 phosphorylates M...

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Detalles Bibliográficos
Autores principales:	Yu, Zheng-Cheng, Huang, Yi-Fu, Shieh, Sheau-Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756815/ https://www.ncbi.nlm.nih.gov/pubmed/26531827 http://dx.doi.org/10.1093/nar/gkv1173

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