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DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions

Although defective repair of DNA double-strand breaks (DSBs) leads to neurodegenerative diseases, the processes underlying their production and signaling in non-replicating cells are largely unknown. Stabilized topoisomerase I cleavage complexes (Top1cc) by natural compounds or common DNA alteration...

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Detalles Bibliográficos
Autores principales:	Cristini, Agnese, Park, Joon-Hyung, Capranico, Giovanni, Legube, Gaëlle, Favre, Gilles, Sordet, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756817/ https://www.ncbi.nlm.nih.gov/pubmed/26578593 http://dx.doi.org/10.1093/nar/gkv1196

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