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Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice

BACKGROUND: Thelper1 (Th1) lymphocytes have been previously implicated in atherosclerotic plaque growth but their role in plaque vulnerability to rupture is less clear. We investigated whether T-bet knockout that prevents Th1 lymphocyte differentiation modulates classical (M1) macrophage activation...

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Detalles Bibliográficos
Autores principales:	Tsaousi, Aikaterini, Hayes, Elaine M., Di Gregoli, Karina, Bond, Andrew R., Bevan, Laura, Thomas, Anita C., Newby, Andrew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757422/ https://www.ncbi.nlm.nih.gov/pubmed/26886778 http://dx.doi.org/10.1371/journal.pone.0148873

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