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LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer

Understanding the mechanisms of androgen receptor (AR) activation in the milieu of low androgen is critical to effective treatment of castration-resistant prostate cancer (CRPC). Here, we report HOTAIR as an androgen-repressed lncRNA, and, as such, it is markedly upregulated following androgen depri...

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Detalles Bibliográficos
Autores principales:	Zhang, Ali, Zhao, Jonathan C., Kim, Jung, Fong, Ka-wing, Yang, Yeqing Angela, Chakravarti, Debabrata, Mo, Yin-Yuan, Yu, Jindan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757469/ https://www.ncbi.nlm.nih.gov/pubmed/26411689 http://dx.doi.org/10.1016/j.celrep.2015.08.069

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