Cargando…

The Mutational Landscape of Acute Promyelocytic Leukemia Reveals an Interacting Network of Co-Occurrences and Recurrent Mutations

Preliminary Acute Promyelocytic Leukemia (APL) whole exome sequencing (WES) studies have identified a huge number of somatic mutations affecting more than a hundred different genes mainly in a non-recurrent manner, suggesting that APL is a heterogeneous disease with secondary relevant changes not ye...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibáñez, Mariam, Carbonell-Caballero, José, García-Alonso, Luz, Such, Esperanza, Jiménez-Almazán, Jorge, Vidal, Enrique, Barragán, Eva, López-Pavía, María, LLop, Marta, Martín, Iván, Gómez-Seguí, Inés, Montesinos, Pau, Sanz, Miguel A., Dopazo, Joaquín, Cervera, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757557/ https://www.ncbi.nlm.nih.gov/pubmed/26886259 http://dx.doi.org/10.1371/journal.pone.0148346

Ejemplares similares

The modular network structure of the mutational landscape of Acute Myeloid Leukemia
por: Ibáñez, Mariam, et al.
Publicado: (2018)

Single-Nucleotide Polymorphism Array-Based Karyotyping of Acute Promyelocytic Leukemia
por: Gómez-Seguí, Inés, et al.
Publicado: (2014)

Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene
por: Liquori, Alessandro, et al.
Publicado: (2020)

Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624
por: Liquori, Alessandro, et al.
Publicado: (2021)

Analysis of SNP Array Abnormalities in Patients with DE NOVO Acute Myeloid Leukemia with Normal Karyotype
por: Ibáñez, Mariam, et al.
Publicado: (2020)

Prognostic impact of gene mutations in myelodysplastic syndromes with ring sideroblasts
por: Martín, Iván, et al.
Publicado: (2017)

Role of Hematopoietic Stem Cell Transplantation in Acute Promyelocytic Leukemia
por: Sanz, Jaime, et al.
Publicado: (2021)

The Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia: Experience of the Pethema Group and Review of the Literature
por: Montesinos, Pau, et al.
Publicado: (2011)

Acute Promyelocytic Leukemia during Pregnancy: A Systematic Review of the Literature
por: Santolaria, Andrea, et al.
Publicado: (2020)

The role of the interactome in the maintenance of deleterious variability in human populations
por: Garcia-Alonso, Luz, et al.
Publicado: (2014)

History of Acute Promyelocytic Leukemia
por: Sanz, Miguel A., et al.
Publicado: (2021)

A Phylogenetic Analysis of 34 Chloroplast Genomes Elucidates the Relationships between Wild and Domestic Species within the Genus Citrus
por: Carbonell-Caballero, Jose, et al.
Publicado: (2015)

IDH1-mutated relapsed or refractory AML: current challenges and future prospects
por: Megías-Vericat, Juan Eduardo, et al.
Publicado: (2019)

A Single-Run Next-Generation Sequencing (NGS) Assay for the Simultaneous Detection of Both Gene Mutations and Large Chromosomal Abnormalities in Patients with Myelodysplastic Syndromes (MDS) and Related Myeloid Neoplasms
por: Liquori, Alessandro, et al.
Publicado: (2021)

Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes
por: Cedena, M. Teresa, et al.
Publicado: (2017)

The pan-cancer pathological regulatory landscape
por: Falco, Matias M., et al.
Publicado: (2016)

Correction: Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes
por: Cedena, M. Teresa, et al.
Publicado: (2018)

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism
por: Mazzarella, Luca, et al.
Publicado: (2020)

Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome
por: Hidalgo, Marta R., et al.
Publicado: (2018)

A comparison of mechanistic signaling pathway activity analysis methods
por: Amadoz, Alicia, et al.
Publicado: (2018)

Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
por: Madan, V, et al.
Publicado: (2016)

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes
por: Hidalgo, Marta R., et al.
Publicado: (2016)

Erratum: Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
por: Madan, V, et al.
Publicado: (2016)

Acute Promyelocytic Leukemia or Acute Myeloid Leukemia with Mutated NPM1?
por: Cloobs-Venezia, Maximiliano, et al.
Publicado: (2022)

Contribution of Mutation and RNA Recombination to the Evolution of a Plant Pathogenic RNA
por: Aranda, Miguel A., et al.
Publicado: (2014)

Case Report: Partial Uniparental Disomy Unmasks a Novel Recessive Mutation in the LYST Gene in a Patient With a Severe Phenotype of Chédiak-Higashi Syndrome
por: Boluda-Navarro, Mireia, et al.
Publicado: (2021)

Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development
por: Millán-Esteban, David, et al.
Publicado: (2021)

The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Trial
por: Ayala, Rosa, et al.
Publicado: (2021)

Mutation Screening of Multiple Genes in Spanish Patients with Autosomal Recessive Retinitis Pigmentosa by Targeted Resequencing
por: González-del Pozo, María, et al.
Publicado: (2011)

Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups
por: Riva, L, et al.
Publicado: (2014)

Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups
por: Riva, L, et al.
Publicado: (2013)

Serial Expression Analysis: a web tool for the analysis of serial gene expression data
por: Nueda, Maria José, et al.
Publicado: (2010)

The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis
por: Picharski, Gledson L., et al.
Publicado: (2019)

PLZF-RAR(α), NPM1-RAR(α), and Other Acute Promyelocytic Leukemia Variants: The PETHEMA Registry Experience and Systematic Literature Review
por: Sobas, Marta, et al.
Publicado: (2020)

Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
por: Valencia, Ana, et al.
Publicado: (2009)

Exome Sequencing Reveals Novel and Recurrent Mutations with Clinical Significance in Inherited Retinal Dystrophies
por: Pozo, María González-del, et al.
Publicado: (2014)

Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
por: Salavert, Francisco, et al.
Publicado: (2016)

Mutation Spectrum of EYS in Spanish Patients with Autosomal Recessive Retinitis Pigmentosa
por: Barragán, Isabel, et al.
Publicado: (2010)

Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia
por: Bochtler, Tilmann, et al.
Publicado: (2016)

Potential Effects of the FLT3-ITD Mutation on Chemotherapy Response and Prognosis of Acute Promyelocytic Leukemia
por: Song, Yu-hua, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sprhsqkmh6u6gma504ab7okdi0