Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes

PURPOSE: To explore the relationship between chronic kidney disease (CKD) and diabetic retinopathy (DR) in a representative population of type 2 diabetes mellitus (DM2) patients in Catalonia (Spain). METHODS: This was a population-based, cross-sectional study. A total of 28,344 patients diagnosed wi...

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Autores principales: Rodríguez-Poncelas, Antonio, Mundet-Tudurí, Xavier, Miravet-Jiménez, Sonia, Casellas, Aina, Barrot-De la Puente, Joan F., Franch-Nadal, Josep, Coll-de Tuero, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757564/
https://www.ncbi.nlm.nih.gov/pubmed/26886129
http://dx.doi.org/10.1371/journal.pone.0149448
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author Rodríguez-Poncelas, Antonio
Mundet-Tudurí, Xavier
Miravet-Jiménez, Sonia
Casellas, Aina
Barrot-De la Puente, Joan F.
Franch-Nadal, Josep
Coll-de Tuero, Gabriel
author_facet Rodríguez-Poncelas, Antonio
Mundet-Tudurí, Xavier
Miravet-Jiménez, Sonia
Casellas, Aina
Barrot-De la Puente, Joan F.
Franch-Nadal, Josep
Coll-de Tuero, Gabriel
author_sort Rodríguez-Poncelas, Antonio
collection PubMed
description PURPOSE: To explore the relationship between chronic kidney disease (CKD) and diabetic retinopathy (DR) in a representative population of type 2 diabetes mellitus (DM2) patients in Catalonia (Spain). METHODS: This was a population-based, cross-sectional study. A total of 28,344 patients diagnosed with DM2 who had recorded ophthalmologic and renal functional examinations were evaluated. Data were obtained from a primary healthcare electronic database of medical records. CKD was defined as an estimated glomerular filtration ratio (eGFR) of <60 ml/min/1.73m(2) and/or urine albumin to creatinine ratio (UACR) ≥30 mg/g. DR was categorized as non-vision threatening diabetic retinopathy and vision threatening diabetic retinopathy. RESULTS: CKD was associated with a higher rate of DR [OR], 95% confidence interval [CI], 1.5 (1.4–1.7). When we analyzed the association between different levels of UACR and DR prevalence observed that DR prevalence rose with the increase of UACR levels, and this association was significant from UACR values ≥10 mg/g, and increased considerably with UACR values ≥300mg/g (Odds ratio [OR], 95% confidence interval [CI], 2.0 (1.6–2.5). This association was lower in patients with eGFR levels 44 to 30 mL/min/1.73m(2) [OR], 95% confidence interval [CI], 1.3 (1.1–1.6). CONCLUSIONS: These results show that CKD, high UACR and/or low eGFR, appear to be associated with DR in this DM2 population.
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spelling pubmed-47575642016-02-26 Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes Rodríguez-Poncelas, Antonio Mundet-Tudurí, Xavier Miravet-Jiménez, Sonia Casellas, Aina Barrot-De la Puente, Joan F. Franch-Nadal, Josep Coll-de Tuero, Gabriel PLoS One Research Article PURPOSE: To explore the relationship between chronic kidney disease (CKD) and diabetic retinopathy (DR) in a representative population of type 2 diabetes mellitus (DM2) patients in Catalonia (Spain). METHODS: This was a population-based, cross-sectional study. A total of 28,344 patients diagnosed with DM2 who had recorded ophthalmologic and renal functional examinations were evaluated. Data were obtained from a primary healthcare electronic database of medical records. CKD was defined as an estimated glomerular filtration ratio (eGFR) of <60 ml/min/1.73m(2) and/or urine albumin to creatinine ratio (UACR) ≥30 mg/g. DR was categorized as non-vision threatening diabetic retinopathy and vision threatening diabetic retinopathy. RESULTS: CKD was associated with a higher rate of DR [OR], 95% confidence interval [CI], 1.5 (1.4–1.7). When we analyzed the association between different levels of UACR and DR prevalence observed that DR prevalence rose with the increase of UACR levels, and this association was significant from UACR values ≥10 mg/g, and increased considerably with UACR values ≥300mg/g (Odds ratio [OR], 95% confidence interval [CI], 2.0 (1.6–2.5). This association was lower in patients with eGFR levels 44 to 30 mL/min/1.73m(2) [OR], 95% confidence interval [CI], 1.3 (1.1–1.6). CONCLUSIONS: These results show that CKD, high UACR and/or low eGFR, appear to be associated with DR in this DM2 population. Public Library of Science 2016-02-17 /pmc/articles/PMC4757564/ /pubmed/26886129 http://dx.doi.org/10.1371/journal.pone.0149448 Text en © 2016 Rodríguez-Poncelas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rodríguez-Poncelas, Antonio
Mundet-Tudurí, Xavier
Miravet-Jiménez, Sonia
Casellas, Aina
Barrot-De la Puente, Joan F.
Franch-Nadal, Josep
Coll-de Tuero, Gabriel
Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes
title Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes
title_full Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes
title_fullStr Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes
title_full_unstemmed Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes
title_short Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes
title_sort chronic kidney disease and diabetic retinopathy in patients with type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757564/
https://www.ncbi.nlm.nih.gov/pubmed/26886129
http://dx.doi.org/10.1371/journal.pone.0149448
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