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Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations
Cells respond to environmental and/or genetic perturbations in order to survive and proliferate. Characterization of the changes after various stimuli at different -omics levels is crucial to comprehend the adaptation of cells to the changing conditions. Genome-wide quantification and analysis of tr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757645/ https://www.ncbi.nlm.nih.gov/pubmed/26925399 http://dx.doi.org/10.3389/fbioe.2016.00017 |
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author | Taymaz-Nikerel, Hilal Cankorur-Cetinkaya, Ayca Kirdar, Betul |
author_facet | Taymaz-Nikerel, Hilal Cankorur-Cetinkaya, Ayca Kirdar, Betul |
author_sort | Taymaz-Nikerel, Hilal |
collection | PubMed |
description | Cells respond to environmental and/or genetic perturbations in order to survive and proliferate. Characterization of the changes after various stimuli at different -omics levels is crucial to comprehend the adaptation of cells to the changing conditions. Genome-wide quantification and analysis of transcript levels, the genes affected by perturbations, extends our understanding of cellular metabolism by pointing out the mechanisms that play role in sensing the stress caused by those perturbations and related signaling pathways, and in this way guides us to achieve endeavors, such as rational engineering of cells or interpretation of disease mechanisms. Saccharomyces cerevisiae as a model system has been studied in response to different perturbations and corresponding transcriptional profiles were followed either statically or/and dynamically, short and long term. This review focuses on response of yeast cells to diverse stress inducing perturbations, including nutritional changes, ionic stress, salt stress, oxidative stress, osmotic shock, and to genetic interventions such as deletion and overexpression of genes. It is aimed to conclude on common regulatory phenomena that allow yeast to organize its transcriptomic response after any perturbation under different external conditions. |
format | Online Article Text |
id | pubmed-4757645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47576452016-02-26 Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations Taymaz-Nikerel, Hilal Cankorur-Cetinkaya, Ayca Kirdar, Betul Front Bioeng Biotechnol Bioengineering and Biotechnology Cells respond to environmental and/or genetic perturbations in order to survive and proliferate. Characterization of the changes after various stimuli at different -omics levels is crucial to comprehend the adaptation of cells to the changing conditions. Genome-wide quantification and analysis of transcript levels, the genes affected by perturbations, extends our understanding of cellular metabolism by pointing out the mechanisms that play role in sensing the stress caused by those perturbations and related signaling pathways, and in this way guides us to achieve endeavors, such as rational engineering of cells or interpretation of disease mechanisms. Saccharomyces cerevisiae as a model system has been studied in response to different perturbations and corresponding transcriptional profiles were followed either statically or/and dynamically, short and long term. This review focuses on response of yeast cells to diverse stress inducing perturbations, including nutritional changes, ionic stress, salt stress, oxidative stress, osmotic shock, and to genetic interventions such as deletion and overexpression of genes. It is aimed to conclude on common regulatory phenomena that allow yeast to organize its transcriptomic response after any perturbation under different external conditions. Frontiers Media S.A. 2016-02-18 /pmc/articles/PMC4757645/ /pubmed/26925399 http://dx.doi.org/10.3389/fbioe.2016.00017 Text en Copyright © 2016 Taymaz-Nikerel, Cankorur-Cetinkaya and Kirdar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Taymaz-Nikerel, Hilal Cankorur-Cetinkaya, Ayca Kirdar, Betul Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations |
title | Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations |
title_full | Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations |
title_fullStr | Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations |
title_full_unstemmed | Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations |
title_short | Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations |
title_sort | genome-wide transcriptional response of saccharomyces cerevisiae to stress-induced perturbations |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757645/ https://www.ncbi.nlm.nih.gov/pubmed/26925399 http://dx.doi.org/10.3389/fbioe.2016.00017 |
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