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Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo
In the cerebellar network, a precise relationship between plasticity and neuronal discharge has been predicted. However, the potential generation of persistent changes in Purkinje cell (PC) spike discharge as a consequence of plasticity following natural stimulation patterns has not been clearly det...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757673/ https://www.ncbi.nlm.nih.gov/pubmed/26924961 http://dx.doi.org/10.3389/fncel.2016.00036 |
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author | Ramakrishnan, K. B. Voges, Kai De Propris, Licia De Zeeuw, Chris I. D’Angelo, Egidio |
author_facet | Ramakrishnan, K. B. Voges, Kai De Propris, Licia De Zeeuw, Chris I. D’Angelo, Egidio |
author_sort | Ramakrishnan, K. B. |
collection | PubMed |
description | In the cerebellar network, a precise relationship between plasticity and neuronal discharge has been predicted. However, the potential generation of persistent changes in Purkinje cell (PC) spike discharge as a consequence of plasticity following natural stimulation patterns has not been clearly determined. Here, we show that facial tactile stimuli organized in theta-patterns can induce stereotyped N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid (GABA-A) receptor-dependent changes in PCs and molecular layer interneurons (MLIs) firing: invariably, all PCs showed a long-lasting increase (Spike-Related Potentiation or SR-P) and MLIs a long-lasting decrease (Spike-Related Suppression or SR-S) in baseline activity and spike response probability. These observations suggests that tactile sensory stimulation engages multiple long-term plastic changes that are distributed along the mossy fiber-parallel fiber (MF-PF) pathway and operate synergistically to potentiate spike generation in PCs. In contrast, theta-pattern electrical stimulation (ES) of PFs indistinctly induced SR-P and SR-S both in PCs and MLIs, suggesting that tactile sensory stimulation preordinates plasticity upstream of the PF-PC synapse. All these effects occurred in the absence of complex spike changes, supporting the theoretical prediction that PC activity is potentiated when the MF-PF system is activated in the absence of conjunctive climbing fiber (CF) activity. |
format | Online Article Text |
id | pubmed-4757673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47576732016-02-26 Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo Ramakrishnan, K. B. Voges, Kai De Propris, Licia De Zeeuw, Chris I. D’Angelo, Egidio Front Cell Neurosci Neuroscience In the cerebellar network, a precise relationship between plasticity and neuronal discharge has been predicted. However, the potential generation of persistent changes in Purkinje cell (PC) spike discharge as a consequence of plasticity following natural stimulation patterns has not been clearly determined. Here, we show that facial tactile stimuli organized in theta-patterns can induce stereotyped N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid (GABA-A) receptor-dependent changes in PCs and molecular layer interneurons (MLIs) firing: invariably, all PCs showed a long-lasting increase (Spike-Related Potentiation or SR-P) and MLIs a long-lasting decrease (Spike-Related Suppression or SR-S) in baseline activity and spike response probability. These observations suggests that tactile sensory stimulation engages multiple long-term plastic changes that are distributed along the mossy fiber-parallel fiber (MF-PF) pathway and operate synergistically to potentiate spike generation in PCs. In contrast, theta-pattern electrical stimulation (ES) of PFs indistinctly induced SR-P and SR-S both in PCs and MLIs, suggesting that tactile sensory stimulation preordinates plasticity upstream of the PF-PC synapse. All these effects occurred in the absence of complex spike changes, supporting the theoretical prediction that PC activity is potentiated when the MF-PF system is activated in the absence of conjunctive climbing fiber (CF) activity. Frontiers Media S.A. 2016-02-18 /pmc/articles/PMC4757673/ /pubmed/26924961 http://dx.doi.org/10.3389/fncel.2016.00036 Text en Copyright © 2016 Ramakrishnan, Voges, De Propris, De Zeeuw and D’Angelo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ramakrishnan, K. B. Voges, Kai De Propris, Licia De Zeeuw, Chris I. D’Angelo, Egidio Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo |
title | Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo |
title_full | Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo |
title_fullStr | Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo |
title_full_unstemmed | Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo |
title_short | Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo |
title_sort | tactile stimulation evokes long-lasting potentiation of purkinje cell discharge in vivo |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757673/ https://www.ncbi.nlm.nih.gov/pubmed/26924961 http://dx.doi.org/10.3389/fncel.2016.00036 |
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