Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular monoamine transporter (VMAT) blocks amphetamine-induced locomotion and self-administration without impacting cocaine-induced beh...

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Detalles Bibliográficos
Autores principales: Freyberg, Zachary, Sonders, Mark S., Aguilar, Jenny I., Hiranita, Takato, Karam, Caline S., Flores, Jorge, Pizzo, Andrea B., Zhang, Yuchao, Farino, Zachary J., Chen, Audrey, Martin, Ciara A., Kopajtic, Theresa A., Fei, Hao, Hu, Gang, Lin, Yi-Ying, Mosharov, Eugene V., McCabe, Brian D., Freyberg, Robin, Wimalasena, Kandatege, Hsin, Ling-Wei, Sames, Dalibor, Krantz, David E., Katz, Jonathan L., Sulzer, David, Javitch, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757768/
https://www.ncbi.nlm.nih.gov/pubmed/26879809
http://dx.doi.org/10.1038/ncomms10652

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