Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling

Importin α1 is involved in nuclear import as a receptor for proteins with a classical nuclear localization signal (cNLS). Here, we report that importin α1 is localized to the cell surface in several cancer cell lines and detected in their cultured medium. We also found that exogenously added importi...

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Detalles Bibliográficos
Autores principales: Yamada, Kohji, Miyamoto, Yoichi, Tsujii, Akira, Moriyama, Tetsuji, Ikuno, Yudai, Shiromizu, Takashi, Serada, Satoshi, Fujimoto, Minoru, Tomonaga, Takeshi, Naka, Tetsuji, Yoneda, Yoshihiro, Oka, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757827/
https://www.ncbi.nlm.nih.gov/pubmed/26887791
http://dx.doi.org/10.1038/srep21410

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