Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss

The hyperphosphorylated microtubule-associated protein tau is present in several neurodegenerative diseases, although the causal relationship remains elusive. Few mouse models used to study Alzheimer-like dementia target tau phosphorylation. We created an inducible pseudophosphorylated tau (Patholog...

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Detalles Bibliográficos
Autores principales: Di, J., Cohen, L. S., Corbo, C. P., Phillips, G. R., El Idrissi, A., Alonso, A. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757872/
https://www.ncbi.nlm.nih.gov/pubmed/26888634
http://dx.doi.org/10.1038/srep20833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757872/
https://www.ncbi.nlm.nih.gov/pubmed/26888634
http://dx.doi.org/10.1038/srep20833

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