The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways

Scleroderma is a group of rare diseases associated with early and transient inflammation and vascular injury, followed by fibrosis affecting the skin and multiple internal organs. Fibroblast activation is the hallmark of scleroderma, and disrupting the intracellular TGFβ signaling may provide a nove...

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Detalles Bibliográficos
Autores principales: del Río, Carmen, Navarrete, Carmen, Collado, Juan A., Bellido, M. Luz, Gómez-Cañas, María, Pazos, M. Ruth, Fernández-Ruiz, Javier, Pollastro, Federica, Appendino, Giovanni, Calzado, Marco A., Cantarero, Irene, Muñoz, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757881/
https://www.ncbi.nlm.nih.gov/pubmed/26887982
http://dx.doi.org/10.1038/srep21703

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