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Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production

Loss of function of the insulin receptor (INSR) in humans produces severe insulin resistance. Unlike “common” insulin resistance, this is associated with elevated plasma levels of the insulin-sensitising, adipose-derived protein adiponectin. The underlying mechanism for this paradox is unclear, and...

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Detalles Bibliográficos
Autores principales:	Groeneveld, Matthijs P., Brierley, Gemma V., Rocha, Nuno M., Siddle, Kenneth, Semple, Robert K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758029/ https://www.ncbi.nlm.nih.gov/pubmed/26888756 http://dx.doi.org/10.1038/srep21105

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