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A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution

Structural and biophysical studies as well as drug screening approaches on G protein-coupled receptors (GPCRs) have been largely hampered by the poor biophysical properties and low expression yields of this largest class of integral membrane proteins. Thermostabilisation of GPCRs by introduction of...

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Detalles Bibliográficos
Autores principales:	Klenk, Christoph, Ehrenmann, Janosch, Schütz, Marco, Plückthun, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758055/ https://www.ncbi.nlm.nih.gov/pubmed/26887595 http://dx.doi.org/10.1038/srep21294

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