Cargando…
The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study
BACKGROUND: Women with gestational diabetes mellitus (GDM) are at an increased risk of developing metabolic syndrome (MetS) after delivery. Recently, the prevalence of both GDM and MetS has increased worldwide, in parallel with obesity. We investigated whether the presentation of MetS and its clinic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758091/ https://www.ncbi.nlm.nih.gov/pubmed/26893617 http://dx.doi.org/10.1186/s13098-015-0038-z |
_version_ | 1782416561051533312 |
---|---|
author | Vilmi-Kerälä, Tiina Palomäki, Outi Vainio, Merja Uotila, Jukka Palomäki, Ari |
author_facet | Vilmi-Kerälä, Tiina Palomäki, Outi Vainio, Merja Uotila, Jukka Palomäki, Ari |
author_sort | Vilmi-Kerälä, Tiina |
collection | PubMed |
description | BACKGROUND: Women with gestational diabetes mellitus (GDM) are at an increased risk of developing metabolic syndrome (MetS) after delivery. Recently, the prevalence of both GDM and MetS has increased worldwide, in parallel with obesity. We investigated whether the presentation of MetS and its clinical features among women with previous GDM differs from that among those with normal glucose tolerance during pregnancy, and whether excess body weight affects the results. METHODS: This hospital-based study of two cohorts was performed in Kanta-Häme Central Hospital, Finland. 120 women with a history of GDM and 120 women with a history of normal glucose metabolism during pregnancy, all aged between 25 and 46 were enrolled. They all underwent physical examination and had baseline blood samples taken. All 240 women were also included in subgroup analyses to study the effect of excess body weight on the results. RESULTS: Although the groups did not differ in body mass index (BMI; p = 0.069), the risk of developing MetS after pregnancy complicated by GDM was significantly higher than after normal pregnancy, 19 vs. 8 cases (p = 0.039). Fasting glucose (p < 0.001) and triglyceride levels (p < 0.001) were significantly higher in women affected. In subgroup analysis, cardiovascular risk factors were more common in participants with high BMI than in those with previous gestational diabetes. CONCLUSIONS: The risk of MetS was 2.4-fold higher after GDM than after normal pregnancy. Cardiovascular risk factors were more common in participants with high BMI than in those with previous GDM. Multivariate analysis supported the main findings. Weight control is important in preventing MetS after delivery. |
format | Online Article Text |
id | pubmed-4758091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47580912016-02-19 The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study Vilmi-Kerälä, Tiina Palomäki, Outi Vainio, Merja Uotila, Jukka Palomäki, Ari Diabetol Metab Syndr Research BACKGROUND: Women with gestational diabetes mellitus (GDM) are at an increased risk of developing metabolic syndrome (MetS) after delivery. Recently, the prevalence of both GDM and MetS has increased worldwide, in parallel with obesity. We investigated whether the presentation of MetS and its clinical features among women with previous GDM differs from that among those with normal glucose tolerance during pregnancy, and whether excess body weight affects the results. METHODS: This hospital-based study of two cohorts was performed in Kanta-Häme Central Hospital, Finland. 120 women with a history of GDM and 120 women with a history of normal glucose metabolism during pregnancy, all aged between 25 and 46 were enrolled. They all underwent physical examination and had baseline blood samples taken. All 240 women were also included in subgroup analyses to study the effect of excess body weight on the results. RESULTS: Although the groups did not differ in body mass index (BMI; p = 0.069), the risk of developing MetS after pregnancy complicated by GDM was significantly higher than after normal pregnancy, 19 vs. 8 cases (p = 0.039). Fasting glucose (p < 0.001) and triglyceride levels (p < 0.001) were significantly higher in women affected. In subgroup analysis, cardiovascular risk factors were more common in participants with high BMI than in those with previous gestational diabetes. CONCLUSIONS: The risk of MetS was 2.4-fold higher after GDM than after normal pregnancy. Cardiovascular risk factors were more common in participants with high BMI than in those with previous GDM. Multivariate analysis supported the main findings. Weight control is important in preventing MetS after delivery. BioMed Central 2015-05-12 /pmc/articles/PMC4758091/ /pubmed/26893617 http://dx.doi.org/10.1186/s13098-015-0038-z Text en © Vilmi-Kerälä et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Vilmi-Kerälä, Tiina Palomäki, Outi Vainio, Merja Uotila, Jukka Palomäki, Ari The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
title | The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
title_full | The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
title_fullStr | The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
title_full_unstemmed | The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
title_short | The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
title_sort | risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758091/ https://www.ncbi.nlm.nih.gov/pubmed/26893617 http://dx.doi.org/10.1186/s13098-015-0038-z |
work_keys_str_mv | AT vilmikeralatiina theriskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT palomakiouti theriskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT vainiomerja theriskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT uotilajukka theriskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT palomakiari theriskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT vilmikeralatiina riskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT palomakiouti riskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT vainiomerja riskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT uotilajukka riskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy AT palomakiari riskofmetabolicsyndromeaftergestationaldiabetesmellitusahospitalbasedcohortstudy |