Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

INTRODUCTION: Increasing evidence implicates the role of the cell types surrounding motor neurons, such as interneurons and glial cells, in non-cell autonomous neurodegeneration of amyotrophic lateral sclerosis (ALS). C-boutons, the large cholinergic synapses that innervate spinal α-motor neurons to...

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Detalles Bibliográficos
Autores principales: Lasiene, Jurate, Komine, Okiru, Fujimori-Tonou, Noriko, Powers, Berit, Endo, Fumito, Watanabe, Seiji, Shijie, Jin, Ravits, John, Horner, Philip, Misawa, Hidemi, Yamanaka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758105/
https://www.ncbi.nlm.nih.gov/pubmed/26891847
http://dx.doi.org/10.1186/s40478-016-0286-7

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