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Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle

BACKGROUND: Low mitochondrial content and oxidative capacity are well-established features of locomotor muscle dysfunction, a prevalent and debilitating systemic occurrence in patients with chronic obstructive pulmonary disease (COPD). Although the exact cause is not firmly established, physical ina...

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Detalles Bibliográficos
Autores principales:	Konokhova, Yana, Spendiff, Sally, Jagoe, R. Thomas, Aare, Sudhakar, Kapchinsky, Sophia, MacMillan, Norah J., Rozakis, Paul, Picard, Martin, Aubertin-Leheudre, Mylène, Pion, Charlotte H., Bourbeau, Jean, Hepple, Russell T., Taivassalo, Tanja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758107/ https://www.ncbi.nlm.nih.gov/pubmed/26893822 http://dx.doi.org/10.1186/s13395-016-0083-9

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