Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed,...

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Detalles Bibliográficos
Autores principales: Uchi, Ryutaro, Takahashi, Yusuke, Niida, Atsushi, Shimamura, Teppei, Hirata, Hidenari, Sugimachi, Keishi, Sawada, Genta, Iwaya, Takeshi, Kurashige, Junji, Shinden, Yoshiaki, Iguchi, Tomohiro, Eguchi, Hidetoshi, Chiba, Kenichi, Shiraishi, Yuichi, Nagae, Genta, Yoshida, Kenichi, Nagata, Yasunobu, Haeno, Hiroshi, Yamamoto, Hirofumi, Ishii, Hideshi, Doki, Yuichiro, Iinuma, Hisae, Sasaki, Shin, Nagayama, Satoshi, Yamada, Kazutaka, Yachida, Shinichi, Kato, Mamoru, Shibata, Tatsuhiro, Oki, Eiji, Saeki, Hiroshi, Shirabe, Ken, Oda, Yoshinao, Maehara, Yoshihiko, Komune, Shizuo, Mori, Masaki, Suzuki, Yutaka, Yamamoto, Ken, Aburatani, Hiroyuki, Ogawa, Seishi, Miyano, Satoru, Mimori, Koshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758664/
https://www.ncbi.nlm.nih.gov/pubmed/26890883
http://dx.doi.org/10.1371/journal.pgen.1005778

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