T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys(319) in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation

Among the human heme-peroxidase family, myeloperoxidase (MPO) has a unique disulfide-linked oligomeric structure resulting from multi-step processing of the pro-protein monomer (proMPO) after it exits the endoplasmic reticulum (ER). Related family members undergo some, but not all, of the processing...

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Detalles Bibliográficos
Autores principales: Laura, Richard P., Dong, David, Reynolds, Wanda F., Maki, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758715/
https://www.ncbi.nlm.nih.gov/pubmed/26890638
http://dx.doi.org/10.1371/journal.pone.0149391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758715/
https://www.ncbi.nlm.nih.gov/pubmed/26890638
http://dx.doi.org/10.1371/journal.pone.0149391

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