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Differential Evolutionary Selection and Natural Evolvability Observed in ALT Proteins of Human Filarial Parasites

The abundant larval transcript (ALT-2) protein is present in all members of the Filarioidea, and has been reported as a potential candidate antigen for a subunit vaccine against lymphatic filariasis. To assess the potential for vaccine escape or heterologous protection, we examined the evolutionary...

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Detalles Bibliográficos
Autores principales:	Devoe, Neil C., Corbett, Ian J., Barker, Linsey, Chang, Robert, Gudis, Polyxeni, Mullen, Nathan, Perez, Kailey, Raposo, Hugo, Scholz, John, May, Meghan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758719/ https://www.ncbi.nlm.nih.gov/pubmed/26890364 http://dx.doi.org/10.1371/journal.pone.0148611

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