Cargando…

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain

Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brumshtein, Boris, Esswein, Shannon R, Salwinski, Lukasz, Phillips, Martin L, Ly, Alan T, Cascio, Duilio, Sawaya, Michael R, Eisenberg, David S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758944/ https://www.ncbi.nlm.nih.gov/pubmed/26576950 http://dx.doi.org/10.7554/eLife.10935

Ejemplares similares

Structure-based inhibitors of amyloid beta core suggest a common interface with tau
por: Griner, Sarah L, et al.
Publicado: (2019)

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity
por: Krotee, Pascal, et al.
Publicado: (2017)

Concentration-dependent polymorphism of insulin amyloid fibrils
por: Sakalauskas, Andrius, et al.
Publicado: (2019)

Ligand-binding characteristics of feline insulin-binding immunoglobulin G
por: SUZUKI, Takafumi, et al.
Publicado: (2015)

Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets
por: Bowler, Jeannette T., et al.
Publicado: (2022)

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation
por: Abskharon, Romany, et al.
Publicado: (2022)

Polymorphism of amyloid-like fibrils can be defined by the concentration of seeds
por: Sneideris, Tomas, et al.
Publicado: (2015)

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
por: Lu, Jiahui, et al.
Publicado: (2020)

Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils
por: Musteikyte, Greta, et al.
Publicado: (2020)

Biochemical and biophysical characterisation of immunoglobulin free light chains derived from an initially unbiased population of patients with light chain disease
por: Sternke-Hoffmann, Rebecca, et al.
Publicado: (2020)

Exploring the potential of deep-blue autofluorescence for monitoring amyloid fibril formation and dissociation
por: Ziaunys, Mantas, et al.
Publicado: (2019)

Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature
por: Ziaunys, Mantas, et al.
Publicado: (2022)

Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives
por: Šneideris, Tomas, et al.
Publicado: (2015)

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
por: Tayeb-Fligelman, Einav, et al.
Publicado: (2023)

Crystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion Disease
por: Apostol, Marcin I., et al.
Publicado: (2010)

β(2)-microglobulin forms 3D domain-swapped amyloid fibrils with disulfide linkages
por: Liu, Cong, et al.
Publicado: (2010)

Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface
por: Warmack, Rebeccah A., et al.
Publicado: (2019)

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies
por: Murray, Kevin A., et al.
Publicado: (2022)

Indexing amyloid peptide diffraction from serial femtosecond crystallography: new algorithms for sparse patterns
por: Brewster, Aaron S., et al.
Publicado: (2015)

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation
por: Xue, Christine, et al.
Publicado: (2017)

Bacterial curli protein promotes the conversion of PAP(248-286) into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences
por: Hartman, Kevin, et al.
Publicado: (2013)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

Involvement of plasminogen activator inhibitor-1 and its related molecules in atrial fibrosis in patients with atrial fibrillation
por: Li, Qiaoqiao, et al.
Publicado: (2021)

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
por: Ereño-Orbea, June, et al.
Publicado: (2018)

Data on immunoglobulin G antibodies induced by immunization of mice with globoside carrying very long-chain fatty acids
por: Okuda, Tetsuya
Publicado: (2018)

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
por: Nyström, Sofie, et al.
Publicado: (2017)

A molecular tweezer antagonizes seminal amyloids and HIV infection
por: Lump, Edina, et al.
Publicado: (2015)

Exploring the occurrence of thioflavin-T-positive insulin amyloid aggregation intermediates
por: Ziaunys, Mantas, et al.
Publicado: (2021)

Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
por: Feng, Fei, et al.
Publicado: (2019)

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
por: Wang, Hansen, et al.
Publicado: (2017)

Interplay between epigallocatechin-3-gallate and ionic strength during amyloid aggregation
por: Ziaunys, Mantas, et al.
Publicado: (2021)

VEGFR-2 conformational switch in response to ligand binding
por: Sarabipour, Sarvenaz, et al.
Publicado: (2016)

Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition
por: Chen, Wenyang, et al.
Publicado: (2018)

Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus
por: Jiang, Jun, et al.
Publicado: (2022)

Proteomic identification of galectin-11 and 14 ligands from Haemonchus contortus
por: Sakthivel, Dhanasekaran, et al.
Publicado: (2018)

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes
por: Rumberger, John M., et al.
Publicado: (2014)

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient
por: Swuec, Paolo, et al.
Publicado: (2019)

Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril
por: Pradhan, Tejaswini, et al.
Publicado: (2020)

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities
por: Lew, Erin D, et al.
Publicado: (2014)

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1
por: Redmond, William John, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pm6teufrf9i8boj2j9im189e1i