Targeting senescent cells enhances adipogenesis and metabolic function in old age

Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhibit adipogenesis in non-senescent progenitors. Blo...

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Detalles Bibliográficos
Autores principales: Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758946/
https://www.ncbi.nlm.nih.gov/pubmed/26687007
http://dx.doi.org/10.7554/eLife.12997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758946/
https://www.ncbi.nlm.nih.gov/pubmed/26687007
http://dx.doi.org/10.7554/eLife.12997

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