Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists

Streptomyces silvensis produces nonribosomal peptides that act as antagonists of the human oxytocin and vasopressin receptors. Here, we present the genome sequence of S. silvensis ATCC 53525 and demonstrate that this organism possesses a number of additional biosynthetic gene clusters and might be a...

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Detalles Bibliográficos
Autores principales: Johnston, Chad W., Li, Yongchang, Magarvey, Nathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759055/
https://www.ncbi.nlm.nih.gov/pubmed/26893408
http://dx.doi.org/10.1128/genomeA.00001-16
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author Johnston, Chad W.
Li, Yongchang
Magarvey, Nathan A.
author_facet Johnston, Chad W.
Li, Yongchang
Magarvey, Nathan A.
author_sort Johnston, Chad W.
collection PubMed
description Streptomyces silvensis produces nonribosomal peptides that act as antagonists of the human oxytocin and vasopressin receptors. Here, we present the genome sequence of S. silvensis ATCC 53525 and demonstrate that this organism possesses a number of additional biosynthetic gene clusters and might be a promising source for genome-guided drug discovery efforts.
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spelling pubmed-47590552016-02-26 Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists Johnston, Chad W. Li, Yongchang Magarvey, Nathan A. Genome Announc Prokaryotes Streptomyces silvensis produces nonribosomal peptides that act as antagonists of the human oxytocin and vasopressin receptors. Here, we present the genome sequence of S. silvensis ATCC 53525 and demonstrate that this organism possesses a number of additional biosynthetic gene clusters and might be a promising source for genome-guided drug discovery efforts. American Society for Microbiology 2016-02-18 /pmc/articles/PMC4759055/ /pubmed/26893408 http://dx.doi.org/10.1128/genomeA.00001-16 Text en Copyright © 2016 Johnston et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Prokaryotes
Johnston, Chad W.
Li, Yongchang
Magarvey, Nathan A.
Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists
title Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists
title_full Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists
title_fullStr Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists
title_full_unstemmed Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists
title_short Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists
title_sort draft genome sequence of streptomyces silvensis atcc 53525, a producer of novel hormone antagonists
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759055/
https://www.ncbi.nlm.nih.gov/pubmed/26893408
http://dx.doi.org/10.1128/genomeA.00001-16
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