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Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment

In a positron-emission tomography (PET) study with the β-amyloid (Aβ) tracer [(18)F]-florbetaben, we previously showed that Aβ deposition in transgenic mice expressing Swedish mutant APP (APP-Swe) mice can be tracked in vivo. γ-Secretase modulators (GSMs) are promising therapeutic agents by reducing...

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Detalles Bibliográficos
Autores principales:	Brendel, M, Jaworska, A, Herms, J, Trambauer, J, Rötzer, C, Gildehaus, F-J, Carlsen, J, Cumming, P, Bylund, J, Luebbers, T, Bartenstein, P, Steiner, H, Haass, C, Baumann, K, Rominger, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759098/ https://www.ncbi.nlm.nih.gov/pubmed/26055427 http://dx.doi.org/10.1038/mp.2015.74

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