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APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease
Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer's disease (AD). Genetic factors may moderate this decline. We examined the role of apolipoprotein E (ɛ4 carrier[ɛ4(+)], ɛ4 non-carrier[ɛ4(−)]) and brain-derived neurotr...
Autores principales: | Lim, Y Y, Villemagne, V L, Laws, S M, Pietrzak, R H, Snyder, P J, Ames, D, Ellis, K A, Harrington, K, Rembach, A, Martins, R N, Rowe, C C, Masters, C L, Maruff, P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759101/ https://www.ncbi.nlm.nih.gov/pubmed/25288138 http://dx.doi.org/10.1038/mp.2014.123 |
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