Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein

Cataract is a protein misfolding disease where the size of the aggregate is directly related to the severity of the disorder. However, the molecular mechanisms that trigger the onset of aggregation remain unknown. Here we use a combination of protein engineering techniques and single-molecule force...

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Detalles Bibliográficos
Autores principales: Garcia-Manyes, Sergi, Giganti, David, Badilla, Carmen L., Lezamiz, Ainhoa, Perales-Calvo, Judit, Beedle, Amy E. M., Fernández, Julio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759196/
https://www.ncbi.nlm.nih.gov/pubmed/26703476
http://dx.doi.org/10.1074/jbc.M115.673871

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