Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration

Major depression brings about a heavy socio-economic burden worldwide due to its high prevalence and the low efficacy of antidepressant drugs, mostly inhibiting the serotonin transporter (SERT). As a result, ~80% of patients show recurrent or chronic depression, resulting in a poor quality of life a...

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Detalles Bibliográficos
Autores principales: Ferrés-Coy, A, Galofré, M, Pilar-Cuéllar, F, Vidal, R, Paz, V, Ruiz-Bronchal, E, Campa, L, Pazos, Á, Caso, J R, Leza, J C, Alvarado, G, Montefeltro, A, Valdizán, E M, Artigas, F, Bortolozzi, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759205/
https://www.ncbi.nlm.nih.gov/pubmed/26100539
http://dx.doi.org/10.1038/mp.2015.80

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