Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression

Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6C(high) monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into macrophages that proliferate locally as disease pr...

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Detalles Bibliográficos
Autores principales: Lindau, Alexandra, Härdtner, Carmen, Hergeth, Sonja P., Blanz, Kelly Daryll, Dufner, Bianca, Hoppe, Natalie, Anto-Michel, Nathaly, Kornemann, Jan, Zou, Jiadai, Gerhardt, Louisa M. S., Heidt, Timo, Willecke, Florian, Geis, Serjosha, Stachon, Peter, Wolf, Dennis, Libby, Peter, Swirski, Filip K., Robbins, Clinton S., McPheat, William, Hawley, Shaun, Braddock, Martin, Gilsbach, Ralf, Hein, Lutz, von zur Mühlen, Constantin, Bode, Christoph, Zirlik, Andreas, Hilgendorf, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759214/
https://www.ncbi.nlm.nih.gov/pubmed/26891724
http://dx.doi.org/10.1007/s00395-016-0535-8

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