DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF...

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Detalles Bibliográficos
Autores principales: He, Tsung-Ying, Wu, De-Wei, Lin, Po-Lin, Wang, Lee, Huang, Chi-Chou, Chou, Ming-Chih, Lee, Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759588/
https://www.ncbi.nlm.nih.gov/pubmed/26892600
http://dx.doi.org/10.1038/srep21483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759588/
https://www.ncbi.nlm.nih.gov/pubmed/26892600
http://dx.doi.org/10.1038/srep21483

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