Efficacy and Safety of rAAV2-ND4 Treatment for Leber’s Hereditary Optic Neuropathy

Leber’s hereditary optic neuropathy (LHON) is a mitochondrially inherited disease leading to blindness. A mitochondrial DNA point mutation at the 11778 nucleotide site of the NADH dehydrogenase subunit 4 (ND4) gene is the most common cause. The aim of this study was to evaluate the efficacy and safe...

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Detalles Bibliográficos
Autores principales: Wan, Xing, Pei, Han, Zhao, Min-jian, Yang, Shuo, Hu, Wei-kun, He, Heng, Ma, Si-qi, Zhang, Ge, Dong, Xiao-yan, Chen, Chen, Wang, Dao-wen, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759604/
https://www.ncbi.nlm.nih.gov/pubmed/26892229
http://dx.doi.org/10.1038/srep21587

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