Cargando…
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlappi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759606/ https://www.ncbi.nlm.nih.gov/pubmed/26643944 http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028 |
| _version_ | 1782416757038776320 |
|---|---|
| author | Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena G. Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen van der Flier, Wiesje Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Rogaeva, Ekaterina St George-Hyslop, Peter Londos, Elisabet Zetterberg, Henrik Ortega-Cubero, Sara Pastor, Pau Ferman, Tanis J. Graff-Radford, Neill R. Ross, Owen A. Barber, Imelda Braae, Anne Brown, Kristelle Morgan, Kevin Maetzler, Walter Berg, Daniela Troakes, Claire Al-Sarraj, Safa Lashley, Tammaryn Compta, Yaroslau Revesz, Tamas Lees, Andrew Cairns, Nigel J. Halliday, Glenda M. Mann, David Pickering-Brown, Stuart Powell, John Lunnon, Katie Lupton, Michelle K. Dickson, Dennis Hardy, John Singleton, Andrew Bras, Jose |
| author_facet | Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena G. Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen van der Flier, Wiesje Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Rogaeva, Ekaterina St George-Hyslop, Peter Londos, Elisabet Zetterberg, Henrik Ortega-Cubero, Sara Pastor, Pau Ferman, Tanis J. Graff-Radford, Neill R. Ross, Owen A. Barber, Imelda Braae, Anne Brown, Kristelle Morgan, Kevin Maetzler, Walter Berg, Daniela Troakes, Claire Al-Sarraj, Safa Lashley, Tammaryn Compta, Yaroslau Revesz, Tamas Lees, Andrew Cairns, Nigel J. Halliday, Glenda M. Mann, David Pickering-Brown, Stuart Powell, John Lunnon, Katie Lupton, Michelle K. Dickson, Dennis Hardy, John Singleton, Andrew Bras, Jose |
| author_sort | Guerreiro, Rita |
| collection | PubMed |
| description | The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| format | Online Article Text |
| id | pubmed-4759606 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47596062016-03-04 Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena G. Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen van der Flier, Wiesje Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Rogaeva, Ekaterina St George-Hyslop, Peter Londos, Elisabet Zetterberg, Henrik Ortega-Cubero, Sara Pastor, Pau Ferman, Tanis J. Graff-Radford, Neill R. Ross, Owen A. Barber, Imelda Braae, Anne Brown, Kristelle Morgan, Kevin Maetzler, Walter Berg, Daniela Troakes, Claire Al-Sarraj, Safa Lashley, Tammaryn Compta, Yaroslau Revesz, Tamas Lees, Andrew Cairns, Nigel J. Halliday, Glenda M. Mann, David Pickering-Brown, Stuart Powell, John Lunnon, Katie Lupton, Michelle K. Dickson, Dennis Hardy, John Singleton, Andrew Bras, Jose Neurobiol Aging Genetic Report Abstract The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Elsevier 2016-02 /pmc/articles/PMC4759606/ /pubmed/26643944 http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Genetic Report Abstract Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena G. Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen van der Flier, Wiesje Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Rogaeva, Ekaterina St George-Hyslop, Peter Londos, Elisabet Zetterberg, Henrik Ortega-Cubero, Sara Pastor, Pau Ferman, Tanis J. Graff-Radford, Neill R. Ross, Owen A. Barber, Imelda Braae, Anne Brown, Kristelle Morgan, Kevin Maetzler, Walter Berg, Daniela Troakes, Claire Al-Sarraj, Safa Lashley, Tammaryn Compta, Yaroslau Revesz, Tamas Lees, Andrew Cairns, Nigel J. Halliday, Glenda M. Mann, David Pickering-Brown, Stuart Powell, John Lunnon, Katie Lupton, Michelle K. Dickson, Dennis Hardy, John Singleton, Andrew Bras, Jose Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_full | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_fullStr | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_full_unstemmed | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_short | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_sort | genome-wide analysis of genetic correlation in dementia with lewy bodies, parkinson's and alzheimer's diseases |
| topic | Genetic Report Abstract |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759606/ https://www.ncbi.nlm.nih.gov/pubmed/26643944 http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028 |
| work_keys_str_mv | AT guerreirorita genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT escottpricevalentina genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT darwentlee genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT parkkinenlaura genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT ansorgeolaf genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT hernandezdenag genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT nallsmichaela genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT clarklorraine genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT honiglawrence genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT marderkaren genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT vanderflierwiesje genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT holstegehenne genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT louwersheimereva genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT lemstraafina genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT scheltensphilip genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT rogaevaekaterina genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT stgeorgehysloppeter genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT londoselisabet genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT zetterberghenrik genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT ortegacuberosara genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT pastorpau genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT fermantanisj genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT graffradfordneillr genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT rossowena genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT barberimelda genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT braaeanne genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT brownkristelle genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT morgankevin genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT maetzlerwalter genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT bergdaniela genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT troakesclaire genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT alsarrajsafa genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT lashleytammaryn genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT comptayaroslau genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT revesztamas genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT leesandrew genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT cairnsnigelj genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT hallidayglendam genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT manndavid genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT pickeringbrownstuart genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT powelljohn genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT lunnonkatie genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT luptonmichellek genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT dicksondennis genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT hardyjohn genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT singletonandrew genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases AT brasjose genomewideanalysisofgeneticcorrelationindementiawithlewybodiesparkinsonsandalzheimersdiseases |