The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

Cancer cells heavily rely on the glycolytic pathway regardless of oxygen tension. Hexokinase II (HKII) catalyses the first irreversible step of glycolysis and is often overexpressed in cancer cells. 3-Bromopyruvate (3BP) has been shown to primarily target HKII, and is a promising anti-cancer compoun...

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Detalles Bibliográficos
Autores principales: Ho, Nelson, Morrison, Jodi, Silva, Andreza, Coomber, Brenda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759612/
https://www.ncbi.nlm.nih.gov/pubmed/26740252
http://dx.doi.org/10.1042/BSR20150267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759612/
https://www.ncbi.nlm.nih.gov/pubmed/26740252
http://dx.doi.org/10.1042/BSR20150267

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