(18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry

[Image: see text] A first-of-its-kind (18)F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA19.9 antibo...

Descripción completa

Detalles Bibliográficos
Autores principales: Meyer, Jan-Philip, Houghton, Jacob L., Kozlowski, Paul, Abdel-Atti, Dalya, Reiner, Thomas, Pillarsetty, Naga Vara Kishore, Scholz, Wolfgang W., Zeglis, Brian M., Lewis, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759614/
https://www.ncbi.nlm.nih.gov/pubmed/26479967
http://dx.doi.org/10.1021/acs.bioconjchem.5b00504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759614/
https://www.ncbi.nlm.nih.gov/pubmed/26479967
http://dx.doi.org/10.1021/acs.bioconjchem.5b00504

Ejemplares similares